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Fundamental Concepts in Organic Reaction Mechanism
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Isomerism

Last Updated : 06 Feb, 2024
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Isomerism refers to the phenomenon where two or more compounds have the same molecular formula but different structural arrangements or spatial orientations, resulting in distinct chemical properties. These compounds with the same formula but different structures are called isomers.

Let's learn about isomerism in detail, including its types and examples.

Isomerism Definition

Isomerism is a chemical phenomenon where two or more compounds have the same molecular formula but different structural arrangements or spatial orientations, resulting in distinct chemical or physical properties.

Isomerism Types

Isomerism can be classified into two categories as follows:

  • Structural or constitutional isomerism
  • Stereoisomerism

Structural Isomerism

Structural isomerism is a type of isomerism where two or more compounds with the same molecular formula have different connectivity or arrangements of atoms in their chemical structures. It is also known as constitutional isomerism.

Because they have the same molecular formula, ethanol, and dimethyl ether are isomers. C2H6O. Because the atoms in each chemical are bonded differently, they are structural isomers.

The following are some examples of structural isomerism in various forms:

  • Chain isomerism
  • Position isomerism
  • Functional isomerism
  • Metamerism
  • Tautomerism
  • Ring chain isomerism

Chain Isomerism

Chain isomers are isomeric substances that differ solely in the arrangement of carbon atoms in the base chain, and chain isomerism is isomerism between them. The carbon atom chain or skeleton differs amongst isomers of this type. 

Carbon atoms can be arranged in a straight or branched chain. Chain isomerism does not exist in molecules comprising up to three carbon atoms since they are a continuous chain with no chance of branching. It is demonstrated for compounds with four or more carbon atoms. 

  • Chain isomerism in alkanes: Alkanes containing four or more carbon atoms. For example, Two chain isomers are represented by the chemical formula C4H10.
Chain isomerism in alkanes
  • Chain isomerism in alkenes: When writing chain isomers for alkenes, the position of the double bond should not be modified. For example, Two chain isomers are represented by the chemical formula C4H8.
Chain isomerism in alkenes
  • Chain isomerism in alkynes: Chain isomerism occurs in alkynes, which are compounds having five or more carbon atoms. The two chain isomers are represented by the chemical formula C5H8.
Chain isomerism in alkynes

Position Isomerism

Position isomerization is a phenomenon that occurs when two or more compounds differ in the position of a component atom or functional group on the carbon skeleton.

C3H8O, for example, is made up of two alcohols:

Position Isomerism of C3H8O

Functional Isomerism

Two or more molecules with the same chemical formula but distinct functional groups are called functional isomers. Functional isomerism is the term for this occurrence. 

For example, the chemical formula C3H6O denotes both an aldehyde and a ketone:

Functional Isomerism of C3H6O

Metamerism

Metamers are molecules that have the same chemical formula but differ in atomic or group locations on both sides of bridge functional groups. They are distinguished by the nature of the alkyl groups surrounding a certain functional group. 

As a result, they have a connection. For example, the chemical formula C4H10O accommodates three metameric isomeric ethers.

Metamerism examples

Tautomerism

Tautomers are functional isomers that exist in dynamic equilibrium at the same time. The most prevalent kind is keto-enol tautomerism, which is caused by the 1,3 movement of the hydrogen atom from carbon to oxygen and vice versa.

For example,

Tautomerism examples

Tautomerism in an aldehyde or ketone requires the existence of a - hydrogen, which is involved in 1,3 – migration. In the lack of a – hydrogen, tautomerism is absent. Acetone, acetaldehyde, and acetophenone, for example, might display tautomerism due to the existence of a—hydrogen, whereas benzaldehyde and benzophenone do not due to the absence of a – hydrogen.

Tautomerism Examples

Ring-chain Isomerism

Ring chain isomerism is structural isomerism that differs from the other structural isomers discussed previously. It is present in isomeric open-chain and cyclic molecules. Compounds with the same chemical formula but open-chain or cyclic structures are known as ring chain isomers. And this phenomenon is known as ring chain isomerism.

The ring chain isomers are represented by the chemical formula C3H6.

Ring-Chain Isomerism

Stereoisomerism

Stereoisomers are compounds that have the same chemical and structural formulae but differ in the relative arrangement of the atoms or groups in space, a phenomenon known as stereoisomerism.

Stereoisomerism can be divided into two categories:

Conformational Isomers

Conformational isomers are stereoisomers having different relative positions of atoms inside the molecule that can be interconverted by rotating around sigma links. In other words, there is no need to break and re-make covalent bonds in order to interconvert these isomers.

Configurational Isomers

Stereoisomers that can only be interconverted by breaking and reconstructing covalent bonds rather than rotating around sigma bonds are known as configurational isomers. Geometrical isomerism and optical isomerism are the two types of configurational isomerism.

Geometrical Isomerism 

Isomerism generated by constrained rotation around a link in a molecule is known as geometrical and also called cis-trans isomerism. A wide range of substances exhibits geometrical isomerism, which can be characterized as follows:

  • C=C, C=N, and N=N are examples of compounds with double bonds.
  • A cyclic molecule, including homocyclic, heterocyclic, and fused ring systems.
  • Steric hindrance compounds prevent rotation around a single bond. Biphenyls, for example.
Geometrical isomerism Examples

Optical Isomerism 

Certain chemicals can exist in two stereoisomeric forms that are incompatible with one another. These isomers have equal physical properties, such as melting point, boiling point, refractive index, density, solubility, and so on, despite the change in atom arrangement.

They are also similar in most of their chemical interactions. They only differ in their behaviour when it comes to plane polarised light; one rotates it to the right, while the other rotates it to the left, but to the same degree. An optical isomer is a pair of chemicals that have the same optical properties.

Optical isomers are two compounds that contain the same number and type of atoms, bonds, and spatial configurations of the atoms but are not superimposable mirror images of each other. Enantiomers are isomers that are non-superimposable mirror reflections of each other.

Optical Isomerism Examples

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Fundamental Concepts in Organic Reaction Mechanism

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