Chromosomal Theory of Inheritance Last Updated : 12 Jan, 2024 Comments Improve Suggest changes Like Article Like Report The essential idea behind the chromosomal theory of inheritance is that genes are located on chromosomes and that the behavior of chromosomes during meiosis and fertilization provides the basis for inheritance patterns. In the early 1900s, pioneering geneticists Walter Sutton and Theodor Boveri formulated this notion. The theory is based on the finding that chromosomes are in charge of transmitting genetic features from generation to generation. During sexual reproduction, the chromosomes of each parent are coupled and then divided during meiosis to form gametes (sperm and egg cells) with one copy of each chromosome. When these gametes merge during fertilization, the resulting zygote has a full set of chromosomes, one from each parent. What is the Chromosomal Theory Of Inheritance?The chromosomal theory of inheritance describes how genetic features are passed down from one generation to the next. Every gene has a precise position on each chromosome that is known as a locus. The expression of these genes, which are present in two copies, one from each parent, can define the physical characteristics of an organism. Morgan and his associates investigated the patterns of inheritance in fruit flies, focusing on the white eye mutation, in the early investigations that gave rise to the chromosomal theory of inheritance. They found that the X-chromosome, one of the two types of sex chromosomes present in many species, contained the gene in question. According to Morgan's research, the sex of the offspring was related to the inheritance of the white-eye feature. While female fruit flies have two X chromosomes, males only had one. This meant that if the white-eye gene was present, it was always expressed because males only have one copy of the gene. On the other hand, the gene might exist in two copies in females, and whether or not it was expressed depended on whether it was dominant or recessive. The function of chromosomes in heredity has been a subject of study since Morgan's original experiments. The idea of genetic recombination, which happens when the chromosomes from the two parents exchange genetic material during meiosis, the process by which gametes (sperm and eggs) are created, has been added to the chromosomal theory of inheritance. Observations of Chromosomal Theory of InheritanceGenetic information is carried by chromosomes: DNA, the genetic information-carrying molecule, makes up chromosomes. Chromosomes include genes, and a gene's precise location on a chromosome is referred to as its locus.Chromosomes act predictably during meiosis: Each gamete receives one copy of each chromosome during meiosis when chromosomes segregate into gametes in a predictable manner. Mendel's law of segregation refers to this.Chromosomes undergo Recombination: Recombination, or the exchange of genetic material between homologous chromosomes, happens during meiosis to create new chromosomes. For offspring to have a diverse genetic makeup, this is crucial.Abnormalities in chromosomes can cause genetic disorders: Chromosome abnormalities can result in genetic illnesses including Down syndrome, Turner syndrome, or Klinefelter syndrome. Chromosome abnormalities can affect the number or shape of chromosomes.The sex of a person is determined by their chromosomes: The existence of particular sex chromosomes in many species, including humans, determines the sex of an individual. People who have two X chromosomes, for instance, are feminine, whereas people who have one X and one Y chromosome are male.Characteristics of Chromosomal Theory of InheritanceGenes are said to be located on chromosomes, which are thread-like structures consisting of DNA and proteins that are found in the nucleus of eukaryotic cells, according to the chromosomal hypothesis of heredity.Each pair of chromosomes has one member that was inherited from each parent.Each gene has a locus, or exact position on a chromosome, where it is found.The expression of these two copies of a gene, one from each parent, which may or may not be identical, can define the physical characteristics of an organism.Genetic recombination, which takes place when the chromosomes from the two parents swap genetic material during meiosis, is another topic covered by the chromosomal theory of inheritance.Structure of Chromosomal Theory of InheritanceChromosomes are compact structures consisting of DNA and proteins that can fit into the nucleus of a cell because of their close packing.Adenine, guanine, cytosine, and thymine are the four nitrogenous bases that make up the DNA molecule. These bases are ordered in a certain sequence to create a code that identifies an organism's genetic information.The proteins connected to DNA have a role in regulating gene expression and chromosomal assembly.Importance of Chromosomal Theory of InheritanceIt is crucial to understand how genetic information is passed down from one generation to the next because of the chromosomal theory of inheritance.It offers a foundation for comprehending how genetic traits are passed down via families and how genes affect how an organism looks.Gene testing, gene therapy, and the investigation of genetic abnormalities are just a few of the genetic technologies and applications that have resulted from it.Types of Chromosomal Theory of InheritanceSex chromosomes and autosomes are the two primary categories of chromosomes.An organism's sex is determined by its sex chromosomes, while other features are controlled by the genes on the autosome.In humans, males have one X and one Y chromosome while females have two X chromosomes.Chromosome abnormalities, such as Down syndrome (caused by an extra copy of chromosome 21) and Turner syndrome (caused by a missing or imperfect X chromosome in females), can result in genetic illnesses.Uses of Chromosomal Theory of InheritanceNumerous aspects of genetics research, such as the investigation of genetic diseases, the creation of genetic tools and treatments, and the study of genetic variation and evolution, all make use of the chromosomal theory of inheritance.Selecting for desirable features in crops and livestock is also done using it in agriculture and animal breeding.The chromosomal theory of inheritance is the foundation for genetic testing, which can be used to detect genetic problems and determine the likelihood that a person will develop specific diseases. Comment More infoAdvertise with us Next Article Linkage And Recombination - Principles Of Inheritance And Variation Class 12 NCERT 00manassucsp Follow Improve Article Tags : School Learning Biology Biology MAQ Similar Reads CBSE Class 12 Biology Syllabus NCERT Class 12 Biology Syllabus: NCERT Class 12 Biology Syllabus covers important topics that provide students with a comprehensive understanding of living organisms, their structure, function, and behavior. These notes introduce fundamental concepts of biology including Sexual reproduction in Flowe 4 min read CBSE Class 12 Biology Notes CBSE Class 12 Chapter-wise Notes Biology helps students to score well in their board examinations. 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